Salmon exosomes and PDRNs: two different ingredients, one goal

The treatment we apply contains two vials with different but complementary active ingredients:

Vial 1 – Exosomes : These are nanovesicles that act as cellular messengers, transporting information between cells and stimulating repair processes. The exosomes in this treatment are obtained from the bacterium Lactobacillus brevis J2K-55, not from salmon sperm.

Vial 2 – Regenerating Complex. Contains a combination of vitamins, growth factors, antioxidants, amino acids, hyaluronic acid, and salmon PDRN . PDRN (Polydeoxyribonucleotide) is a fragment of DNA extracted from salmon, highly compatible with the human body due to its similarity to our own DNA. This allows it to interact directly with skin cells to activate their natural repair and regeneration mechanisms. It is a widely studied ingredient with solid scientific backing and an excellent safety profile.

What does the Salmon Exosome and PDRN Application consist of and what is it used for?

PDRN is a fragment of DNA extracted from salmon sperm that acts by stimulating adenosine receptors in fibroblasts—the cells responsible for producing collagen and elastin—thus activating collagen synthesis, tissue regeneration, and reducing inflammation.

It is applied topically in combination with microneedling, depending on the treatment goal. It is ideal for facial rejuvenation, improving skin texture and overall quality.

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What are the benefits of Exosome Application and PDRN in Salmon?

  • Deep cellular regeneration
  • Stimulation of collagen and elastin
  • Excellent complement for stain reduction.
  • Improved texture, firmness and radiance
  • Anti-inflammatory and healing effect

How long does the Salmon Exosomes and PDRN session last?

At Naturalness, the session lasts approximately 60 minutes, depending on the area to be treated and the application technique defined by the attending physician.

When are the results seen and how often is it done?

The first results can be seen within the first 48 to 72 hours, with progressive improvement over the following weeks as cellular regeneration processes are activated. A minimum initial protocol of 3 sessions at 4-5 week intervals is recommended, followed by periodic maintenance sessions as determined by the physician.

Does the application of Exosomes and PDRN from Salmon cause pain, disability, or have side effects?

Salmon PDRN and Exsosome therapy is very well tolerated. There may be some transient redness or tenderness in the treated area. It does not cause any downtime, and the patient can resume their normal activities the same day, following the post-procedure care instructions. As it is a molecule biocompatible with human DNA, its safety profile is very high. At Naturalness, we have trained medical personnel who guarantee a safe procedure with appropriate support for each patient’s well-being. 

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